Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.
BackgroundAlthough reduced glutathione (rGSH) is decreased in obese mice and humans, block of GSH synthesis by buthionine sulfoximine (BSO) results in a lean, insulin-sensitive phenotype.Data is lacking about the effect of BSO on GSH precursors, cysteine and glutamate.Plasma total cysteine (tCys) is positively associated with stearoyl-coenzyme A de